Wondering what is Hypercholesterolemia? It is when there are high concentrations of cholesterol in your blood. To make things clear to you, again cholesterol is a waxy, fat-like substance found in all cells of our body which aids in making of hormones, vitamin D and other substances that help us digest foods. However, an excess of this cholesterol in your blood can make you sick. Recently, Turmeric in Hypercholesterolemia has gained utmost importance being an active compound to lower and control cholesterol level. Turmeric in Hypercholesterolemia acts in multidimensional way due to the presence of its main component Curcumin exerting key roles to lower bad cholesterol (LDL) in blood. Turmeric in Hypercholesterolemia increases serum vitamin E concentration that improves anti-oxidant protection which significantly reduces lipid peroxidation in the liver. A healthy liver means low cholesterol in blood.
What are LDL & HDL?
Cholesterol does not get dissolved in water and therefore, it cannot travel through the body by itself. Fat particles known as lipoproteins help transport cholesterol through the bloodstream and prevents from getting accumulated. There are two major forms of lipoproteins: Low-density lipoproteins (LDL), commonly known as “bad cholesterol” as it can accumulate in the arteries and lead to problems like heart attack or stroke. High-density lipoproteins (HDL), called as “good cholesterol” which aids return of LDL cholesterol to the liver for elimination.
Turmeric in Hypercholesterolemia also prevents accumulation of bad cholesterol inside your arteries that could lead to multiple heart conditions. Turmeric in Hypercholesterolemia has proven role in preventing the onset of the disease and its related complications.
Hypercholesterolemia is a medical condition characterized by high levels of cholesterol in the blood. It is a form of high level of lipids and in fact one form of hyperlipidemia i.e. high level of fat/lipids in blood. Familial Hypercholesterolemia (FH) is known to be most common inherited type of hyperlipidemia. This condition predisposes sufferers to premature abnormal hardening of the inner layer of arteries (arteriosclerosis) including coronary artery disease with incidences of heart attacks at an unusually young age. It is believed that half of men and a third of women suffer from heart attack before the age of 50.
Familial Hypercholesterolemia is attributed to a genetic defect in the receptor (i.e. the dock on the surface of cells) for LDL (low density lipoprotein or bad cholesterol). Turmeric in Hypercholesterolemia holds grounds on the basis of its magical powers to put a control on bad cholesterol and safeguarding liver cells.
Turmeric in Hypercholesterolemia appears to have the ability to lower cholesterol production in the liver and block cholesterol absorption in the gut. Turmeric in Hypercholesterolemia also reduces LDL cholesterol oxidation in the lining of the arteries as turmeric is a natural anti-oxidant.
Hypercholesterolemia is a major risk factor along with smoking, hypertension and diabetes for developing atherosclerosis. Coronary heart disease is almost entirely due to atherosclerosis in the coronary arteries. Atherosclerosis in the carotid arteries also plays a major role in stroke.
Turmeric in Hypercholesterolemia plays diverse anti-inflammatory, anti-oxidant and lipid lowering properties and proposes itself to be a promising agent lowering and controlling incidences of atherosclerosis.
How Hypercholesterolemia Manifests?
Typically, high cholesterol does not cause any symptoms until it gets build up inside your blood vessels to the limit that it restricts blood flow. In most cases it only causes emergency events such as a heart attack or stroke resulting from damage caused by high cholesterol.
Surprisingly hypercholesterolemia itself has no obvious symptoms to warn the patient. It can only be diagnosed with blood test. You must keep a check on your cholesterol level frequently if you have a family history of high cholesterol or are having any of the following risk factors:
- High blood pressure
- Overweight/ High Body Mass Index (BMI)
- Alcohol consumption
Causes of Hypercholesterolemia
- Familial hypercholesterolemia – This is usually an inherited condition where liver may take too much cholesterol and body is not able to eliminate bad cholesterol from the blood efficiently.
- High fat diet – Having a diet rich in polysaturated and transfats (such as processed or fried food) is another cause of high cholesterol levels in blood.
- Lifestyle issues– Being overweight and having a sedentary lifestyle is another cause of hypercholesterolemia.
- Diabetes -Some diseases such as diabetes is associated with hypercholesterolemia as well.
Who Are at Risks?
The following are considered as risk factors for hypercholesterolemia:
- Poor dietary habits — People eating saturated fats which are mostly found in animal products and trans-fats which come from some commercially baked cookies, doughnuts, cream filled candies, and margarine can raise cholesterol level. Also, foods that are high in cholesterol such as red meat and full-fat dairy products are also known culprits for increasing total cholesterol level.
- Lack of exercise – It is a known fact that regular exercise is very important in bringing up HDL or “good” cholesterol concentration and lowers the LDL or “bad” cholesterol.
- Obesity – Cholesterol is directly related to BMI. The total cholesterol level rises with the rise in BMI. Having a body mass index (BMI) of 30 or greater puts you at risk of high cholesterol.
- Large waist circumference — A person is considered increased risk if he is a man with a waist circumference of at least 40 inches (102 centimeters) or a woman with a waist circumference of at least 35 inches (89 centimeters).
- Diabetes — High blood sugar levels are known to contribute towards higher LDL cholesterol and lower HDL cholesterol. Not only this, constantly higher levels of blood sugar also damage the lining of arteries.
- Smoking — Smoking cigarettes ends up damaging the walls of blood vessels and makes them prone to fatty deposit accumulation. In addition, smoking can also lower the level of HDL or “good” cholesterol.
- Sedentary Lifestyle — It is well established that being physically active plays a very important role in cholesterol levels and an exercise threshold must be met to boost HDL or good cholesterol.
Unavoidable Complications Arising from Hypercholesterolemia
- Angina or Chest pain — this is the condition where a patient experiences intense chest pain like a pressure or squeezing sensation. It is usually a symptom of an underlying heart problem and occurs when arteries that supply blood to the heart (coronary arteries) are blocked with the cholesterol.
- Acute coronary syndrome — It is a medical term referring to a group of conditions occurring due to reduced decreased amount of blood flow in the coronary arteries that supply blood to heart.
- Premature heart disease — Excessive amounts of bad cholesterol in the blood leads to thickening of arterial linings and they gradually change form from tiny crystals to larger deposits of fats and eventually these plaques grow into blockages. When a clot or blockage completely obstructs an artery, it deprives heart of oxygen rich blood leading to heart attack. Atherosclerosis (hardening and narrowing of the arteries) has been identified in patients as young as 15 during studies.
- Heart attack — If plaques tear or rupture, a blood clot may form at the plaque-rupture site — blocking the flow of blood or breaking free and plugging an artery downstream. If blood flow to part of your heart stops, you’ll have a heart attack.
- Stroke — In a similar fashion to a heart attack, if oxygen rich blood supply to any part of brain gets blocked by a clot, a stroke occurs which commonly results in disabling conditions like paralysis.
How to Check on Hypercholesterolemia?
Typically a blood test called as lipid panel is done to diagnose hypercholesterolemia. A lipid panel usually consists measurement of total cholesterol, HDL cholesterol, LDL cholesterol, and triglycerides (fats in the blood). In order to get accurate results, fasting of about 12 hours before the sample is taken is recommended.
Ways to Prevent That You Must Know:
- It is very important to cut down on saturated and trans-fats in the diet. Choosing healthy fats such as olive oil and canola oil helps increase the level of good cholesterol.
- Regular exercising regime is very important to keep the weight within healthy range.
- Optimal BMI should be aimed upon.
- Increased intake of dietary fiber such as oats, salads, fruits and vegetables, is very helpful in reducing total cholesterol level. Plant based diet are associated with reduced LDL levels.
- Fatty fish about twice a week helps increase level of good cholesterol.
Turmeric in Hypercholesterolemia – Benefits & Outcomes
There have been numerous studies suggesting that Turmeric in Hypercholesterolemia can reverse the effects as it has the ability to reduce cholesterol levels in the blood and as such preventing plaque build-up in the arteries. Turmeric in Hypercholesterolemia exhibits the following effects:
- When bad cholesterol or LDL oxidizes in the body, it leads to accumulation of fatty streaks along the arterial walls. Curcumin present in turmeric helps prevent arterial blockage as it inhibits this oxidation process.
- Furthermore, Turmeric in Hypercholesterolemia also acts as a vasodilator helping in the dilation (opening up) of the blood vessels and thus reducing the possibility of blockage. Also, turmeric has the ability of to prevent aggregation of blood platelets and inhibit blood clot formation.
- Turmeric in Hypercholesterolemia is famous for its anti-inflammatory properties and as such prevents inflammatory deposits on the inner walls of the blood vessels.
- Anti-oxidant properties of the turmeric help reduce formation of free radicals which are highly reactive in order to prevent further inflammation.
- Curcumin contained in turmeric lowers LDL cholesterol and prevent its oxidation and thus suppressing the build-up of plaque in arteries which can lead to heart disease and stroke. Turmeric has a unique ability to prevent cholesterol production in the liver and also it blocks cholesterol absorption in the gut thus reducing LDL cholesterol oxidation in the lining of the arteries.
However, Turmeric in Hypercholesterolemia fails to exert 100% of its therapeutic effect due to:
- Poor bioavailability
- Less permeability and extensive systemic metabolism
- Need to be combined with additional compounds to improve absorption
- Turmeric root contains only about 1-3% of Curcumin
- Non-standardized powdered turmeric root entails intake of large dose in order to derive any benefit
Keeping in mind the disadvantages of Turmeric/Curcumin, SNEC 30 (Self Nano Emulsifying Curcumin 30mg), a latest generation of scientifically formulated bioactive has been co-developed by Arbro Pharmaceuticals Pvt. Ltd, DRDO (Defense Research & Development Organization), and Jamia Hamdard University in collaboration with DST (Department of Science & Technology, GOI). There is US Patent for the technology used in SNEC 30.
SNEC 30 uses Self Nano-Emulsifying Drug Delivery System (SNEDDS) which makes the properties of Curcumin to multifold. SNEC 30 is patented through the prestigious United States Patent for drug delivery system that helps it to achieve maximum concentration in blood (Cmax) several times more compared to its’ closest rival. Self nano-emulsifying curcumin used in SNEC 30 acts fast with lower doses without causing any adverse effects.
Highlights of SNEC 30
- SNEC 30 Uses SNEDDS for better Absorption, Highest Bioavailability of Curcumin & Fast Action Mode
The US patented formulation of SNEC 30 is based on Self Nano Emulsifying Drug Delivery System (SNEDDS) that helps it to achieve Cmax (peak serum concentration of any drug) of active curcuminoids several times more than its’ closest rival. SNEC 30 forms a stable nano emulsion in stomach and bypasses the pre-systemic metabolism followed by absorption through the lipid absorption channel and the payers’ patches in the intestines. It also escapes Liver First Pass and directly reaches into systemic blood through lymphatic system providing the basis for high Cmax at a very low dose.
- SNEC 30 has “NO Side Effects”
SNEC 30 works in a synchronized fashion working on cellular membranes to organize them more orderly. This not only improves the resistance of cells against infection and malignancy as well as works on various receptors to control inflammation and pain without causing any adverse effects.
- SNEC 30 is a Superior Anti-Oxidant
SNEC 30, due to its unique US patented formulation, neutralizes free radicals which makes it the best anti-oxidant. Its immunomodulatory action strengthens body’s immunity to fight against most microbial infections. SNEC 30 also exerts antimicrobial and disinfectant properties for a wide range of topical bacterial and fungal infections.
SNEC 30 – Attacks on Hypercholesterolemia:
SNEC 30 is highly effective in controlling Hypercholesterolemia as discussed below:
- SNEC 30 has the ability to prevent oxidation of bad cholesterol – uniquely patented Curcumin formulation present in SNEC 30 has antioxidant properties due to which bad cholesterol is not oxidized and thus deposits on arterial walls are not formed.
- Promotes Metabolism of cholesterol in Liver – Liver possesses certain lipoprotein and cholesterol receptors that identify free cholesterol and LDL and take them up for processing and metabolize for easy excretion which reduces cholesterol level in blood and thus lowers risk of hypercholesterolemia.
SNEC 30 is an extremely efficient agent in increasing cholesterol uptake by the liver cells and enhances cholesterol metabolism.
- Reduction of total cholesterol and absorption of clots – another important cause of atherosclerosis of aggregation of platelets and response of inflammatory cells at the site of injury. SNEC 30 exceptionally prevents this arterial thrombosis and aggregate formation and hence prevents cholesterol absorption in the gut.
- Curcumin in SNEC 30 promotes dilation of arteries – atherosclerosis is known to reduce supply of oxygenated blood in the body due to underlying arterial blockage. SNEC 30 relaxes the arteries thus opening them up and enabling good circulation.
- SNEC 30 prevents platelet aggregation—recent studies have shown that Curcumin present in SNEC 30 has anticoagulant properties and thus helps in prevention of blood clot formation.
- SNEC 30 inhibits plaque formation – the medicine is proven to inhibit plaque formation on arterial walls as it stops proliferation of vascular smooth muscle cells.
- SNEC 30 helps in weight loss – it helps in losing weight by inhibiting the differentiation of fat producing cells also known as adipocytes.
Dosage and Safety:
SNEC 30 is completely safe even at very high doses but ideal dose should be customized according to individual body requirement. Trials generally report very few, if any, adverse effects of SNEC 30 even at very high dose. There have been no reports of toxicity following even large amount of turmeric ingestion.
All the information on this site is for the purpose of general education and in no way can substitute the consultation with an Ayurvedic doctor. It is highly recommended that you consult with your Ayurvedic doctor or health care provider to determine the individual requirements. Pregnant women, nursing mothers and children should not take any supplements without consulting their doctor.